Anti-angiogenic and anti-neuroinflammatory effects of kallistatin through interactions with the canonical Wnt pathway Running title: kallistatin and diabetic retinopathy
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Corresponding Authors: Jian-xing Ma, MD, PhD. (To be contact) BSEB 328B, 941 Stanton L. Young Blvd, Oklahoma City, OK 73104-5020 Fax: (405) 271-3973; Telephone: (405) 271-4372 Email: [email protected] Zuguo Liu, MD, PhD Eye institute of Xiamen University, 168 Daxue Road, Xiamen, Fujian, 361005, China Fax: 86-592-2183761; Telephone: 86-592-2186901 Email: [email protected] Page 1 of 48 Diabetes
منابع مشابه
Antiangiogenic and Antineuroinflammatory Effects of Kallistatin Through Interactions With the Canonical Wnt Pathway
Kallistatin is a member of the serine proteinase inhibitor superfamily. Kallistatin levels have been shown to be decreased in the vitreous while increased in the circulation of patients with diabetic retinopathy (DR). Overactivation of the Wnt pathway is known to play pathogenic roles in DR. To investigate the role of kallistatin in DR and in Wnt pathway activation, we generated kallistatin tra...
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In this issue, Liu et al. (1) reported that kallistatin, an endogenous Wnt antagonist, exerted antiangiogenic and antineuroinflammatory effects by inhibiting canonical Wnt signaling in diabetic retinopathy (DR) mouse models. DR is one of the most common microvascular complications of diabetes, characterized by retinal vascular leakage, inflammation, and abnormal neovascularization (2,3). DR has...
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Wound healing, angiogenesis, and hair follicle maintenance are often impaired in the skin of diabetic patients, but the pathogenesis has not been well understood. Here, we report that circulation levels of kallistatin, a member of the serine proteinase inhibitor (SERPIN) superfamily with antiangiogenic activities, were elevated in type 2 diabetic patients with diabetic vascular complications. T...
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Kallistatin has been recognized as an endogenous angiogenic inhibitor. However, its effects on lymphatic endothelial cells and lymphangiogenesis remain poorly understood. Lymphangiogenesis is involved in tumor metastasis via the lymphatic vasculature in various types of tumors. The aim of this study was to investigate the effects of kallistatin on lymphangiogenesis and the mechanism of action i...
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Kallistatin is an endogenous protein that exerts pleiotropic effects, including vasodilation and inhibition of angiogenesis, inflammation, oxidative stress, apoptosis, fibrosis, and tumor progression. Through its 2 functional domains—an active site and a heparin-binding site—kallistatin regulates differential signaling pathways and a wide spectrum of biological functions. Kallistatin’s active s...
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تاریخ انتشار 2013